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慢性非癌痛中阿片类药物滥用的预防:一种基于算法和循证的方法。

Prevention of opioid abuse in chronic non-cancer pain: an algorithmic, evidence based approach.

机构信息

Tri State Spine Care Institute, Cincinnati, OH 45230, USA.

出版信息

Pain Physician. 2012 Jul;15(3 Suppl):ES177-89.

Abstract

BACKGROUND

The use of opioids for chronic non-cancer pain has grown exponentially in the last 15 years. Associated with that, dramatic increases in abuse and overdose deaths from opioid use have been noted.

OBJECTIVES

Most opioid abuse stems from legitimate prescriptions, putting the onus on prescribers to use opioids responsibly for chronic pain. Very little evidence-based guidance exists for those who wish to prescribe opioids for legitimate chronic pain and at the same time prevent opioid abuse.

METHODS

A review of literature was performed for articles focused on guidelines for opioid use when prescribed for chronic pain, opioid abuse, and overdose, strategies to detect and prevent abuse of opioids, urine drug screens (UDS) in chronic pain settings, prescription monitoring programs (PMP), and the relationship between opioid dosing and abuse.

RESULTS

Based on the existing literature, an evidence-based algorithmic approach was developed to decrease opioid abuse in the chronic pain environment. The pillars of prevention are the screening of patients into high, medium, and low risk categories using screening tools; monitoring patients using UDS, PMP, and pill counts, and lastly, dose limitations.

CONCLUSION

This algorithmic approach may enable physicians to prescribe opioids for patients with chronic pain and also to reduce opioid abuse.

摘要

背景

在过去的 15 年中,阿片类药物在慢性非癌症疼痛中的使用呈指数级增长。与之相关的是,阿片类药物滥用和过量使用导致的死亡人数也急剧增加。

目的

大多数阿片类药物滥用源于合法处方,因此,医生有责任合理开具阿片类药物治疗慢性疼痛,并同时防止阿片类药物滥用。对于那些希望为合法的慢性疼痛开具阿片类药物处方,同时防止阿片类药物滥用的医生来说,几乎没有基于证据的指导。

方法

对关于慢性疼痛时开具阿片类药物的指南、阿片类药物滥用和过量、检测和预防阿片类药物滥用的策略、慢性疼痛环境中的尿液药物筛查(UDS)、处方监测计划(PMP)以及阿片类药物剂量与滥用之间的关系的文献进行了综述。

结果

根据现有文献,制定了一种循证算法方法,以减少慢性疼痛环境中的阿片类药物滥用。预防的基础是使用筛查工具将患者分为高、中、低风险类别进行筛查;使用 UDS、PMP 和药丸计数监测患者;最后是剂量限制。

结论

这种算法方法可以使医生为慢性疼痛患者开具阿片类药物处方,并减少阿片类药物滥用。

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