Department of Oncology, Janssen Research and Development, a division of Janssen Pharmaceutica, Beerse, Belgium.
Cancer Res. 2012 Aug 1;72(15):3709-14. doi: 10.1158/0008-5472.CAN-11-4112. Epub 2012 Jul 10.
ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Acetyl CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications. Acetyl CoA is also required for acetylation reactions that modify proteins, such as histone acetylation. ACLY is upregulated or activated in several types of cancers, and its inhibition is known to induce proliferation arrest in cancer cells both in vitro and in vivo. The present review highlights current knowledge about the role of ACLY in cancer cells, with special reference to the different pathways that are linked by ACLY.
三磷酸腺苷柠檬酸裂解酶（ACLY）是一种胞质酶，能够催化柠檬酸生成乙酰辅酶 A。乙酰辅酶 A 是内源性脂肪酸和胆固醇生物合成的重要组成部分，参与异戊烯基化蛋白修饰。乙酰辅酶 A 也是修饰蛋白质的乙酰化反应所必需的，如组蛋白乙酰化。在几种类型的癌症中，ACLY 上调或激活，其抑制作用已知可在体外和体内诱导癌细胞增殖停滞。本综述强调了 ACLY 在癌细胞中的作用的现有知识，特别提到了 ACLY 相关的不同途径。
