Neuroscience Education Institute.
CNS Spectr. 2012 Jun;17(2):63-9. doi: 10.1017/S1092852912000442.
A medication's pharmacokinetic properties can be as important as its efficacy in determining how successful a treatment is. Formulation plays a critical role in absorption, distribution, and elimination of a drug, which in turn can influence the clinical profile of a medication, including onset and duration of action, consistency of plasma levels, ability to cross the blood-brain barrier, and other factors. Advances in drug delivery technology mean that formulation is now an integral component in the development of a drug. Likewise, formulation is one of the factors that may influence selection of a medication to suit the needs of a particular patient. This article briefly reviews the technologies commonly applied in the development of psychotropic medications, with emphasis on the various oral modified-release formulations, and discusses how formulation can be used to optimize the efficacy and tolerability of psychotropic drugs.
药物的药代动力学特性与其疗效一样，对于确定治疗的成功程度至关重要。制剂在药物的吸收、分布和消除中起着关键作用，这反过来又会影响药物的临床特征，包括作用的开始和持续时间、血浆水平的一致性、穿越血脑屏障的能力以及其他因素。药物输送技术的进步意味着制剂现在是药物开发的一个组成部分。同样，制剂也是影响选择适合特定患者需求的药物的因素之一。本文简要回顾了常用于开发精神药物的技术，重点介绍了各种口服改良释放制剂，并讨论了如何通过制剂来优化精神药物的疗效和耐受性。
