Department of Neurosciences and Mental Health, Federal University of Bahia, Salvador, Brazil.
CNS Spectr. 2012 Jun;17(2):70-5. doi: 10.1017/S1092852912000466.
Four studies have found a smaller amygdalar volume in patients with borderline personality disorder (BPD) relative to controls, whereas four other studies have found similar amygdalar volume in BPD patients relative to controls. This study aims to compare amygdalar volumes of BPD patients with controls, and also to compare BPD patients with and without post-traumatic stress disorder (PTSD) with controls in order to determine whether PTSD can explain the heterogeneity of findings.
Systematic review and meta-analysis of magnetic resonance imaging studies that measured amygdalar volumes in BPD patients and healthy controls.
A significant reduction of amygdalar volumes in BPD patients was confirmed (p < .001). However, data from the studies that discriminated BPD patients with and without PTSD indicated that amygdalar volumes were significantly smaller in BPD patients without PTSD relative to controls (left: p = .02; right: p = .05), but not in BPD patients with PTSD relative to controls (left: p = .08; right: p = .20).
This meta-analysis suggests that amygdalar volumes are reduced in patients with BPD. This pattern is confirmed in BPD patients without PTSD, but not in BPD patients with PTSD, raising the possibility that reduced amygdalar volume in BPD patients cannot be explained by comorbid PTSD.
四项研究发现，与对照组相比，边缘型人格障碍（BPD）患者的杏仁核体积较小，而另外四项研究发现，BPD 患者的杏仁核体积与对照组相似。本研究旨在比较 BPD 患者和对照组的杏仁核体积，以及比较伴有和不伴有创伤后应激障碍（PTSD）的 BPD 患者与对照组的杏仁核体积，以确定 PTSD 是否可以解释研究结果的异质性。
对测量 BPD 患者和健康对照组杏仁核体积的磁共振成像研究进行系统回顾和荟萃分析。
证实 BPD 患者的杏仁核体积显著减小（p <.001）。然而，区分伴有和不伴有 PTSD 的 BPD 患者的研究数据表明，与对照组相比，无 PTSD 的 BPD 患者的杏仁核体积显著较小（左侧：p =.02；右侧：p =.05），但伴有 PTSD 的 BPD 患者的杏仁核体积与对照组相比无显著差异（左侧：p =.08；右侧：p =.20）。
这项荟萃分析表明，BPD 患者的杏仁核体积减小。这种模式在无 PTSD 的 BPD 患者中得到证实，但在伴有 PTSD 的 BPD 患者中则不然，这表明 BPD 患者杏仁核体积减小不能用共病 PTSD 来解释。
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