Nakazawa Toshiyuki, Hirono Yasuo, Koneri Kenji, Nagano Hideki, Murakami Makoto, Goi Takanori, Iida Atsushi, Katayama Kanji, Ito Hirofumi, Yamaguchi Akio
First Department of Surgery, University of Fukui, Japan.
Nihon Shokakibyo Gakkai Zasshi. 2012 Jul;109(7):1204-12.
A 69-year-old man was admitted with fatigue, anorexia, and slight fever. Gastroscopy showed a tumor in the stomach, and biopsy revealed a poorly differentiated adenocarcinoma. CT scan revealed a tumor of the stomach, a tumor in the lower lobe of the right lung, and multiple tumors in the liver. Moreover, he was drowsy, probably caused by severe hypocalcemia thought to be caused by parathyroid hormone related protein. We treated him with S-1, but the gastric tumors progressed rapidly and massive pleural effusion developed. He died on the 16th day after admission. At autopsy, the histology of the lung tumor was found to be pleomorphic carcinoma, and that had metastasized to the stomach, the liver, and other abdominal organs. We treated a rare case of pleomorphic carcinoma with hypercalcemia that was discovered due to gastric metastasis.
一名69岁男性因疲劳、厌食和低热入院。胃镜检查显示胃内有肿瘤,活检显示为低分化腺癌。CT扫描显示胃有肿瘤、右肺下叶有肿瘤以及肝脏有多个肿瘤。此外,他嗜睡,可能是由甲状旁腺激素相关蛋白导致的严重低钙血症引起的。我们用S-1对他进行治疗,但胃肿瘤进展迅速,出现了大量胸腔积液。他在入院后第16天死亡。尸检发现肺肿瘤的组织学类型为多形性癌,且已转移至胃、肝脏和其他腹部器官。我们治疗了一例因胃转移而发现的伴有高钙血症的罕见多形性癌病例。