Kim H S, Jang W I, Hong H S, Lee C I, Lee D K, Yong S J, Shin K C, Shim Y H
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Korea.
J Korean Med Sci. 1993 Feb;8(1):24-9. doi: 10.3346/jkms.1993.8.1.24.
Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of the stomach secondary to lung carcinoma were diagnosed by gastroscopy. The first patient was a 66-year-old man who had primary lung carcinoma with multiple bone and subcutaneous metastases. Gastroscopy showed multiple submucosal tumors with central umbilications in the fundus and in the upper body of the stomach. Pathologic examination revealed massive submucosal infiltration and conical shaped and scanty deep mucosal infiltration of undifferentiated small cell carcinoma suggestive of metastatic involvement. The second patient was a 68-year-old man who had primary lung carcinoma with brain metastasis. Gastroscopy showed a large fungating mass in the greater curvature side of the stomach. Pathologic examination revealed poorly differentiated squamous cell carcinoma. We report the two cases of metastatic gastric cancer from lung carcinoma with the literature review.
血行转移至胃的癌是一种罕见情况。根据文献报道数量，经血流转移至胃的最常见肿瘤是恶性黑色素瘤、乳腺癌和肺癌。最近，通过胃镜诊断出两例继发于肺癌的胃转移病例。首例患者为一名66岁男性，患有原发性肺癌并伴有多处骨和皮下转移。胃镜检查显示胃底和胃体上部有多个中央凹陷的黏膜下肿瘤。病理检查显示大量黏膜下浸润以及未分化小细胞癌呈圆锥形且深部黏膜浸润稀少，提示为转移所致。第二例患者为一名68岁男性，患有原发性肺癌并伴有脑转移。胃镜检查显示胃大弯侧有一个巨大的蕈伞状肿物。病理检查显示为低分化鳞状细胞癌。我们报告这两例肺癌转移至胃癌的病例并进行文献复习。
