Kawata Keishi, Hanawa Takehisa, Endo Naoko, Suzuki Masahiko, Oguchi Toshio
Department of Pharmacy, University of Yamanashi Hospital, Shimokato, Chuo, Yamanashi, Japan.
Chem Pharm Bull (Tokyo). 2012;60(7):825-30. doi: 10.1248/cpb.c110500.
In the present study, all-trans retinoic acid (RA) gels formulated with various compositions of polyethylene oxide (Emulgen®) and iota-carrageenan (ι-CG) were prepared and their physicochemical properties were evaluated. The compression energy, which is the work required to compress the product through a fixed distance, increased with increasing amount of ι-CG or Emulgen®. The adhesion energy and displacement decreased with increasing amount of ι-CG or Emulgen® due to the progression of gel formation. From the results of the sensory tests, the properties of RA gels such as adhesiveness, gel strength and spreadability seemed to be adjustable depending on the condition of skin by varying the components of RA gels. Through photostability study, the expiration date and storage conditions of RA gels were determined as "4°C for 28 d with no exposure to light."
在本研究中，制备了用不同组成的聚环氧乙烷（乳化剂®）和ι-卡拉胶（ι-CG）配制的全反式维甲酸（RA）凝胶，并对其理化性质进行了评估。压缩能量是将产品压缩固定距离所需的功，随着ι-CG或乳化剂®用量的增加而增加。由于凝胶形成过程，粘附能量和位移随着ι-CG或乳化剂®用量的增加而降低。从感官测试结果来看，通过改变RA凝胶的成分，RA凝胶的粘性、凝胶强度和铺展性等性质似乎可根据皮肤状况进行调节。通过光稳定性研究，RA凝胶的有效期和储存条件确定为“4℃，28天，无光照”。
