Luo Zhen-Hua, He Shuang-Yan, Chen Bao-Quan, Shi Yan-Ping, Liu Yu-Ming, Li Cai-Wen, Wang Qiu-Sheng
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Binshui West Road 391, Tianjin, P.R. China.
Chem Pharm Bull (Tokyo). 2012;60(7):887-91. doi: 10.1248/cpb.c12-00250.
A series of novel 1,3,4-oxadiazole derivatives based on benzisoselenazolone has been prepared and tested for antiproliferative activity in vitro against the cells of human cancer cell lines: SSMC-7721 (human liver cancer cell), MCF-7 (human breast cancer cell) and A549 (human lung cancer cell). All the compounds obtained exhibited antiproliferative activity and showed selective cytotoxicity against different cancer cells. Compounds 7d and 7i showed significant antiproliferative activities against MCF-7 cells, with IC50 values of 1.07 and 1.76 µM respectively. Compound 7d were found to be the most potent compound against SSMC-7721 cells, with IC50 values 4.46 µM.
基于苯并异硒唑酮制备了一系列新型1,3,4-恶二唑衍生物，并对其进行体外抗增殖活性测试，以检测其对人癌细胞系细胞的作用：SSMC-7721（人肝癌细胞）、MCF-7（人乳腺癌细胞）和A549（人肺癌细胞）。所有得到的化合物均表现出抗增殖活性，并对不同癌细胞显示出选择性细胞毒性。化合物7d和7i对MCF-7细胞显示出显著的抗增殖活性，IC50值分别为1.07和1.76μM。发现化合物7d是对SSMC-7721细胞最有效的化合物，IC50值为4.46μM。
