Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic.
Metallomics. 2012 Aug;4(8):739-50. doi: 10.1039/c2mt20081c. Epub 2012 Jul 13.
Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.
金属硫蛋白（MT）是一组普遍存在的蛋白质，其作用在众多论文中仍在讨论，但它们与一些金属离子的亲和力是无可争议的。这些富含半胱氨酸的蛋白质与抗氧化活性和保护生物分子免受自由基，特别是活性氧的作用有关。在这篇综述中，锌（II）离子、活性氧、重金属离子和金属硫蛋白之间的关系，以及这些蛋白质对细胞增殖的影响和在抵抗重金属和非重金属药物方面可能的负面作用进行了阐述。
