B 型利钠肽水平与无双胎输血综合征的单绒毛膜-双羊膜双胞胎的出生体重差异相关。

B-type natriuretic peptide levels are correlated with birth-weight discordance in monochorionic-diamniotic twins without twin-twin transfusion syndrome.

机构信息

Maternity and Perinatal Care Center, Hokkaido University Hospital, Sapporo, Japan.

出版信息

J Perinatol. 2013 Mar;33(3):182-7. doi: 10.1038/jp.2012.94. Epub 2012 Jul 12.

DOI:10.1038/jp.2012.94

PMID:22791277

Abstract

OBJECTIVE

To determine whether B-type natriuretic peptide (BNP) levels in umbilical cord blood (UCB) and amniotic fluid (AF) are correlated with birth-weight discordances in monochorionic-diamniotic twins.

STUDY DESIGN

The UCB-BNP and AF-BNP levels were determined at birth in 36 twin-pairs without twin-twin transfusion syndrome (TTTS).

RESULT

Both the UCB-BNP and the AF-BNP levels were significantly higher among twins with either a birth-weight discordance ≥20% (141.6 versus 52.9 pg ml(-1) for UCB-BNP, 38.0 versus 17.2 pg ml(-1) for AF-BNP) or cardiac dysfunction at birth (167.2 versus 56.3 pg ml(-1) for UCB-BNP, 34.9 versus 19.0 pg ml(-1) for AF-BNP), compared with neonates without the respective characteristics. The UCB-BNP and AF-BNP levels in both the larger and the smaller twins were significantly correlated with birth-weight discordance.

CONCLUSION

Cardiac dysfunction occurs in both larger and smaller co-twins with increasing birth-weight discordances, even in the absence of TTTS.

摘要

目的

确定单纯双羊膜囊双胎中脐血（UCB）和羊水（AF）中 B 型利钠肽（BNP）水平与出生体重差异是否相关。

研究设计

在无双胎输血综合征（TTTS）的 36 对双胎中，于出生时测定 UCB-BNP 和 AF-BNP 水平。

结果

无论是出生体重差异≥20%（UCB-BNP 为 141.6 比 52.9 pg/ml，AF-BNP 为 38.0 比 17.2 pg/ml）还是出生时存在心功能障碍的双胎（UCB-BNP 为 167.2 比 56.3 pg/ml，AF-BNP 为 34.9 比 19.0 pg/ml），其 UCB-BNP 和 AF-BNP 水平均显著高于无相应特征的新生儿。较大和较小双胞胎的 UCB-BNP 和 AF-BNP 水平与出生体重差异均呈显著相关。