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Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency.

作者信息

Pantazis Panayotis, Dimas Konstantinos, Wyche James H, Anant Shrikant, Houchen Courtney W, Panyam Jayanth, Ramanujam Rama P

机构信息

ADNA, Inc, Oklahoma City, OK, USA.

出版信息

Methods Mol Biol. 2012;906:311-9. doi: 10.1007/978-1-61779-953-2_25.

DOI:10.1007/978-1-61779-953-2_25
PMID:22791444
Abstract

Nanoparticles (NPs) formulated using poly (D,L-lactide-co-glycolide) (PLGA), a biodegradable, biocompatible, and clinically approved polymer, have been widely used for targeted drug delivery. Here we provide methods for preparing PLGA NPs that encapsulate small interfering RNA (siRNA). The siRNA NPs are formulated using a double-emulsion solvent evaporation technique with the addition of a small amount of the cationic polymer, polyethyleneimine, which significantly increases siRNA encapsulation.

摘要

相似文献

[1]
Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency.

Methods Mol Biol. 2012

[2]
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[3]
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[7]
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[8]
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[9]
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[10]
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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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[10]
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