Department of Endocrinology and Metabolism, The General Hospital of Jinan Military Command, China.
J Renin Angiotensin Aldosterone Syst. 2013 Sep;14(3):255-62. doi: 10.1177/1470320312452768. Epub 2012 Jul 12.
Epidemiological studies investigating the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphism and PCOS, we conducted the current meta-analysis.
PubMed, Web of Science and CNKI were searched for eligible publications up to 1 February 2012. The association was evaluated under different genetic models.
Six studies with 1451 cases and 773 controls were finally included in our meta-analysis. The results showed that no significant association between I/D polymorphism and PCOS was observed in the overall population. However, in subgroup analyses stratified by ethnicity, significant association was observed in Caucasians (OR = 1.48, 95% CI, 1.00-2.19 for D vs. I; OR = 1.61, 95% CI, 1.14-2.27 for DD vs. II; OR = 1.43, 95% CI, 1.04-1.97 for DD and DI vs. II), but not in Asians.
Our meta-analysis suggested that the ACE I/D polymorphism was associated with increased risk of PCOS in Caucasians, but not in Asians. However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings.
流行病学研究调查血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与多囊卵巢综合征（PCOS）之间的关联产生了不一致的结果。为了更精确地评估 I/D 多态性与 PCOS 之间的关系，我们进行了本次荟萃分析。
检索了 PubMed、Web of Science 和中国知网（CNKI），以获取截至 2012 年 2 月 1 日的相关文献。评估了不同遗传模型下的相关性。
最终纳入了 6 项研究，共包含 1451 例病例和 773 例对照。结果表明，总体人群中 I/D 多态性与 PCOS 之间无显著相关性。然而，在按种族分层的亚组分析中，在白种人群中观察到显著相关性（D 等位基因与 I 等位基因相比，OR=1.48，95%CI，1.00-2.19；DD 基因型与 II 基因型相比，OR=1.61，95%CI，1.14-2.27；DD 和 DI 基因型与 II 基因型相比，OR=1.43，95%CI，1.04-1.97），而在亚洲人群中则无显著相关性。
我们的荟萃分析表明，ACE I/D 多态性与白种人群 PCOS 的发病风险增加相关，但与亚洲人群无关。然而，考虑到结论基于相对较小的样本量，未来的研究应该涉及不同种族人群，以验证我们的发现。
