Corrado Mauro, Scorrano Luca, Campello Silvia
University of Geneva, 1211 Geneva, Switzerland.
Int J Cell Biol. 2012;2012:729290. doi: 10.1155/2012/729290. Epub 2012 Jun 27.
Mitochondria are key organelles in the cell, hosting essential functions, from biosynthetic and metabolic pathways, to oxidative phosphorylation and ATP production, from calcium buffering to red-ox homeostasis and apoptotic signalling pathways. Mitochondria are also dynamic organelles, continuously fusing and dividing, and their localization, size and trafficking are finely regulated. Moreover, in recent decades, alterations in mitochondrial function and dynamics have been implicated in an increasing number of diseases. In this review, we focus on the relationship clarified hitherto between mitochondrial dynamics and cancer, neurodegenerative and neuroinflammatory diseases.
线粒体是细胞中的关键细胞器，承担着从生物合成和代谢途径到氧化磷酸化及ATP生成，从钙缓冲到氧化还原稳态和凋亡信号通路等重要功能。线粒体也是动态细胞器，不断进行融合和分裂，其定位、大小和运输受到精细调控。此外，近几十年来，线粒体功能和动态变化与越来越多的疾病有关。在本综述中，我们聚焦于迄今已阐明的线粒体动态变化与癌症、神经退行性疾病和神经炎症性疾病之间的关系。
