Yang Fang, Wan Li, Hu Yichen, Lv Wei, Zhang Yi
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):956-60.
To develop a quantitative analysis of multi-components by single marker(QAMS) method for simultaneous determination of three coumarins in Angelica dahurica var. formosana, by using one standard substance.
With imperatorin as internal reference standard, and 2 relative correction factors (RCF) to imperatorin were calculated within certain ranges. Their contents in 20 batches of samples, collected from different areas, were determined by both external standard method and QAMS. The method was evaluated by comparison of the quantitative results between the two methods.
No significant differences were found in the quantitative results of three coumarins in 20 batches of A. dahurica var. formosana determined by the two methods (RSD < 5%).
QAMS is feasible and suitable for quality control of A. dahurica var. formosana.
建立一种单指标多成分定量分析（QAMS）方法，采用一种对照品同时测定台湾当归中3种香豆素类成分。
以欧前胡素为内参比对照品，在一定范围内计算得到2个相对校正因子（RCF）。采用外标法和QAMS法分别测定20批不同产地台湾当归中3种香豆素类成分的含量，并比较两种方法的定量结果来评价该方法。
两种方法测定20批台湾当归中3种香豆素类成分的定量结果无显著差异（RSD<5%）。
QAMS法可行，适用于台湾当归的质量控制。
