Zhan H T, Mo D X
Fo Shan Medical School for Adult.
Zhonghua Bing Li Xue Za Zhi. 1990 Sep;19(3):191-3.
By using undecalcified bone sections, accompanied by tetracycline double labeling and bone histomorphometry, the influence of different concentrations of fluoride on induced ectopic bone formation and mineralization during the 21th-30th day of the experiment was observed. Results showed that on the 30th day, the induced bone formation in the group of 50ppm NaF was more active than that of the control; and from the 21th day to the 26th day as well as from the 26th day to the 30th day, no inhibition of mineralization was obtained in the same group. The induced bone formation and mineralization in the group of 200ppm NaF was severely inhibited from the 21th day to the 26th day; on the 30th day, the quantity of induced bone was markedly reduced, and many woven bones were also present there.
通过使用不脱钙骨切片，结合四环素双标记和骨组织形态计量学，观察了不同浓度氟化物在实验第21天至30天对诱导异位骨形成和矿化的影响。结果显示，在第30天，50ppm氟化钠组的诱导骨形成比对照组更活跃；并且在同一组中，从第21天到第26天以及从第26天到第30天，未观察到矿化受到抑制。在200ppm氟化钠组中，从第21天到第26天诱导骨形成和矿化受到严重抑制；在第30天，诱导骨的数量明显减少，并且还存在许多编织骨。
