Liverpool Sarcoma Unit, Royal Liverpool and Broadgreen University Hospitals, Liverpool, UK.
Biomarkers. 2012 Sep;17(6):539-44. doi: 10.3109/1354750X.2012.699554. Epub 2012 Jul 16.
Elevated neutrophil to lymphocyte ratio has been identified as a prognostic indicator in malignancies whereas; its association with extremity and trunk soft tissue sarcoma remain unclear. The aim of this study is to determine the utility of full blood neutrophil lymphocyte ratio (NLR) in preoperative diagnosis and its predictive value for survival in patients managed for soft tissue sarcoma of the trunk and extremities.
223 patients who presented with a soft tissue tumor were retrospectively reviewed. The study period was from January 2002-December 2009. Preoperative NLR as well as demographics, clinical and histopathological data were analysed.
Full blood NLR was significantly higher in patient with a soft tissue sarcoma compared to benign soft tissue tumors (p < 0.001). Cox regression analysis demonstrated that elevated NLR >5 (p < 0.05) may be an adverse prognostic factor for Overall Survival.
The preoperative NLR is a simple, investigation predicting the preoperative diagnosis of a soft tissue sarcoma and a predictor of worse overall survival for patient with a soft tissue sarcoma.
高中性粒细胞与淋巴细胞比值已被确定为恶性肿瘤的预后指标，而其与肢体和躯干软组织肉瘤的关系尚不清楚。本研究旨在确定全血中性粒细胞与淋巴细胞比值（NLR）在术前诊断中的效用及其对肢体软组织肉瘤患者生存的预测价值。
回顾性分析了 223 例软组织肿瘤患者的资料。研究期间为 2002 年 1 月至 2009 年 12 月。分析了术前 NLR 以及人口统计学、临床和组织病理学资料。
与良性软组织肿瘤相比，软组织肉瘤患者的全血 NLR 明显升高（p < 0.001）。Cox 回归分析表明，升高的 NLR >5（p < 0.05）可能是总生存的不良预后因素。
术前 NLR 是一种简单的、有助于术前诊断软组织肉瘤的检查指标，也是软组织肉瘤患者总生存较差的预测指标。
