Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
J Microencapsul. 2013;30(2):143-50. doi: 10.3109/02652048.2012.704953. Epub 2012 Jul 16.
The therapeutic efficiency and topical performance of drug-containing microcapsules varied when the drugs existed in an internal oil phase or an internal aqueous phase within the wall shell or wall matrix of microcapsules. In this study, chitosan-based (oil-in-water) and agar-gelatin-based (water-in-oil) microencapsulation systems containing berberine were applied to cotton fabrics to provide an anti-Staphylococcus aureus activity for textile materials. The berberine microcapsule-treated cotton samples were subjected to various washing cycles and their surface morphology, chemical compositions and antibacterial property were investigated after washing. The SEM images and Fourier transform infrared analysis showed that the amount of microcapsules on cotton samples decreased gradually with an increase in washing cycles. After 20 washing cycles, the cotton fabrics with agar-gelatin (water-in-oil) microcapsules containing berberine still exhibited the anti-S. aureus activity. However, the chitosan-based (oil-in-water) system did not show any growth inhibition towards S. aureus but only in the contact areas.
当药物存在于微胶囊的壁壳或壁基质的内部油相或内部水相中时，含药物的微胶囊的治疗效率和局部性能会发生变化。在本研究中，壳聚糖（油包水）和琼脂-明胶（水包油）载有小檗碱的微胶囊系统被应用于棉织物，为纺织材料提供抗金黄色葡萄球菌的活性。对经小檗碱微胶囊处理的棉样进行了各种洗涤循环，并在洗涤后对其表面形态、化学成分和抗菌性能进行了研究。SEM 图像和傅里叶变换红外分析表明，随着洗涤循环次数的增加，棉样上的微胶囊数量逐渐减少。经过 20 次洗涤循环后，含有小檗碱的琼脂-明胶（水包油）微胶囊的棉织物仍表现出抗金黄色葡萄球菌的活性。然而，壳聚糖（油包水）体系对金黄色葡萄球菌没有表现出任何抑制生长的作用，而只是在接触区域。
