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儿茶酚胺对肝脏代谢的α-肾上腺素能效应所涉及的机制。

Mechanisms involved in alpha-adrenergic effects of catecholamines on liver metabolism.

作者信息

Exton J H

出版信息

J Cyclic Nucleotide Res. 1979;5(4):277-87.

PMID:227945
Abstract

Recent results have indicated that alpha-adrenergic receptors are the major mediators of catecholamine actions on liver metabolism in several species. It is well-established that cAMP and cAMP-dependent protein kinase are not involved in hepatic alpha-adrenergic effects. This review presents evidence that alpha-adrenergic stimulation of glycogenolysis in rat liver involves the mobilization of Ca2+ ions from mitochondria and stimulation of phosphorylase kinase by the resulting increase in cytosolic Ca2+ concentration. Possible mechanisms by which activation of alpha-adrenergic receptors causes release of mitochondrial Ca2+ and affects other cell processes are discussed.

摘要

最近的研究结果表明，α-肾上腺素能受体是几种物种中儿茶酚胺对肝脏代谢作用的主要介质。众所周知，环磷酸腺苷（cAMP）和cAMP依赖性蛋白激酶不参与肝脏α-肾上腺素能效应。这篇综述提供了证据，表明大鼠肝脏中α-肾上腺素能刺激糖原分解涉及从线粒体动员钙离子，并通过由此导致的胞质钙离子浓度增加来刺激磷酸化酶激酶。文中还讨论了α-肾上腺素能受体激活导致线粒体钙离子释放并影响其他细胞过程的可能机制。

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1
Mechanisms involved in alpha-adrenergic effects of catecholamines on liver metabolism.儿茶酚胺对肝脏代谢的α-肾上腺素能效应所涉及的机制。
J Cyclic Nucleotide Res. 1979;5(4):277-87.
2
Mechanisms of catecholamine actions on liver carbohydrate metabolism.儿茶酚胺对肝脏碳水化合物代谢的作用机制。
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Role of cyclic AMP in the actions of catecholamines on hepatic carbohydrate metabolism.环磷酸腺苷在儿茶酚胺对肝脏碳水化合物代谢作用中的角色。
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Evidence for alpha adrenergic activation of phosphorylase and inactivation of glycogen synthase in rat adipocytes. Effects of alpha and beta adrenergic agonists and antagonists on glycogen synthase and phosphorylase.大鼠脂肪细胞中α-肾上腺素能激活磷酸化酶及糖原合酶失活的证据。α-和β-肾上腺素能激动剂与拮抗剂对糖原合酶和磷酸化酶的影响。
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