Coşkun T, Ozalp I, Kale G, Göğüş S
Division of Metabolism, Hacettepe University, Ankara, Turkey.
Eur J Pediatr. 1990 Dec;150(2):109-10. doi: 10.1007/BF02072050.
Two patients with phenylketonuria and scleroderma-like skin lesions are presented. Since scleroderma is a rare collagen disease of childhood, the occurrence of these two disorders in the same patient does not seem to be coincidental but raises the possibility of a causal relationship. Improvement in the skin lesions of the patients after the commencement of a low-phenylalanine diet supports this hypothesis.
本文报告了两名患有苯丙酮尿症并伴有硬皮病样皮肤病变的患者。由于硬皮病是一种罕见的儿童胶原疾病，这两种病症在同一患者身上出现似乎并非偶然，而是提示了存在因果关系的可能性。患者在开始低苯丙氨酸饮食后皮肤病变有所改善，这支持了这一假说。
