Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.
J Clin Psychiatry. 2012 Jun;73(6):e725-7. doi: 10.4088/JCP.12f07732.
Smoking is associated with the induction of the CYP 1A2 enzyme, and hence with diminished levels of drugs metabolized by this enzyme. This article presents a hypothetical patient, diagnosed with schizophrenia, who smokes about 10 cigarettes a day. The progress of the patient is examined across several follow up meetings, each of which presents a fresh clinical problem related to smoking and its interaction with the medication. Clinical guidance for each problem is presented along with a brief discussion on the subject. The article concludes with a discussion of other pharmacokinetic considerations related to smoking and its treatment in patients with schizophrenia.
吸烟可诱导 CYP1A2 酶的产生，从而降低该酶代谢的药物水平。本文介绍了一位假设的患者，该患者被诊断患有精神分裂症，每天吸烟约 10 支。通过几次随访检查来观察患者的病情进展，每次随访都会提出一个与吸烟及其与药物相互作用有关的新的临床问题。针对每个问题都提供了临床指导，并对该主题进行了简要讨论。文章最后讨论了与吸烟及其在精神分裂症患者中的治疗相关的其他药代动力学注意事项。
