Shimizu H, Shimomura Y, Uehara Y, Kobayashi I, Kobayashi S
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Exp Clin Endocrinol. 1990 Sep;96(1):25-9. doi: 10.1055/s-0029-1210984.
The effect of estrogen supplement on selective D2 receptor antagonist sulpiride induced weight gain was examined in ovariectomized (ovx.) rats. Sulpiride injection (10 mg/kg, s.c.) showed a significant increase of body weight and food consumption only in female rats. Bilateral ovariectomy completely abolished the weight gain and hyperphagia by sulpiride. Subcutaneous injection of estradiol benzoate (E2:5 micrograms/day, s.c.) for 14 days restored the effects of sulpiride on weight gain in ovx, rats and sulpiride injection with E2 supplement significantly increased the efficiency of food utilization. The present study suggested that estrogen should be involved in the induction of overweight and hyperphagia by sulpiride.
在去卵巢大鼠中研究了补充雌激素对选择性D2受体拮抗剂舒必利诱导体重增加的影响。仅在雌性大鼠中，注射舒必利（10mg/kg，皮下注射）显示体重和食物摄入量显著增加。双侧卵巢切除完全消除了舒必利引起的体重增加和食欲亢进。皮下注射苯甲酸雌二醇（E2：5微克/天，皮下注射）14天可恢复舒必利对去卵巢大鼠体重增加的影响，补充E2注射舒必利可显著提高食物利用效率。本研究表明，雌激素应参与舒必利诱导的超重和食欲亢进。
