Dept. of Neurology, Christian-Albrecht-University, Kiel, Germany.
Parkinsonism Relat Disord. 2013 Jan;19(1):32-6. doi: 10.1016/j.parkreldis.2012.06.018. Epub 2012 Jul 12.
Parkinsonian patients demonstrate particular difficulties when performing sequential motor tasks compared to simple movements indicating an important role of the basal ganglia in switching between different motor programs.
To investigate the impact of subthalamic stimulation on the kinematics of composed reach-to-grasp movements and on isolated movement segments.
11 age matched controls and 16 PD patients with subthalamic stimulation were examined without medication with stimulation switched on and off. All subjects were instructed to perform three different externally cued hand movements: 1) The complete reach-to-grasp movement consisting of hand transport to and precision grip around a target. 2) The isolated reach movement to the grip device 3) The isolated precision grip and button press. Kinematic data were recorded with a 3D ultrasound movement analysis system (CMS 70 P4-V5, Zebris, Germany).
The effect of subthalamic stimulation was accentuated during the reach phase compared to the grip formation during the composed movement. Stimulation induced kinematic changes of the composed movement were comparable to those of both isolated submovements.
Subthalamic stimulation improved certain aspects of all three hand movement types but did not differentially impact the composed reach-to-grasp task compared to the simple submovements. We assume that the complete reach-to-grasp task is encoded in a single generalised motor program which is affected by stimulation.
与简单运动相比，帕金森病患者在执行连续运动任务时表现出特别的困难，这表明基底神经节在不同运动程序之间的切换中起着重要作用。
研究丘脑下刺激对组合伸手抓握运动的运动学和孤立运动段的影响。
11 名年龄匹配的对照组和 16 名接受丘脑下刺激的 PD 患者在不服用药物的情况下进行了检查，刺激开和关。所有受试者均被指示执行三种不同的外部提示手运动：1）完整的伸手抓握运动，包括手向目标的运输和精确握持。2）到达握持装置的孤立伸手运动 3）孤立的精确握持和按钮按压。运动学数据使用三维超声运动分析系统（CMS 70 P4-V5，Zebris，德国）记录。
与组合运动中的握持形成相比，丘脑下刺激在伸手阶段的效果更为明显。组合运动的刺激诱导运动学变化与两个孤立的亚运动相似。
丘脑下刺激改善了所有三种手运动类型的某些方面，但与简单的亚运动相比，对组合的伸手抓握任务没有产生不同的影响。我们假设完整的伸手抓握任务是在单个通用运动程序中编码的，该程序受刺激的影响。
