早产儿和三胞胎妊娠发生囊腔性脑室内白质软化的风险增加。
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia.
机构信息
Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Austria.
出版信息
Eur J Paediatr Neurol. 2013 Mar;17(2):148-52. doi: 10.1016/j.ejpn.2012.06.010. Epub 2012 Jul 12.
BACKGROUND
An increased risk of cerebral palsy in multiples has been reported.
AIMS
To determine the risk for the development of periventricular leukomalacia (PVL) of twin and triplet pregnancy.
STUDY DESIGN
Retrospective single-centre study at a tertiary care university hospital.
SUBJECTS
Infants ≤ 35 weeks gestational age born between 1988 and 2008.
OUTCOME MEASURES
Risk of twin and triplet compared to singleton pregnancy regarding development of PVL in one offspring.
RESULTS
Of 6195 infants 117 singletons and 39 multiples were diagnosed as having cystic PVL. Perinatal data did not differ as did not ultrasonographic findings and neurologic outcome. The relative risk (RR) of a twin pregnancy resulting in at least one infant with PVL when born prior to 36 weeks was 2.181 (CI 95% 1.474-3.228, p < .0001), and 6.793 (CI 95% 2.470-13.108, p < .0001) of a triplet pregnancy. In-vitro fertilisation was present in 3% of affected twins compared to 100% in triplets (p < .001).
CONCLUSION
We found an increased risk for PVL in preterm twin and triplet pregnancies.
背景
已有研究报道，多胎妊娠发生脑瘫的风险增加。
目的
确定双胎和三胎妊娠发生脑室周围白质软化（PVL）的风险。
研究设计
在一家三级保健大学医院进行的回顾性单中心研究。
研究对象
1988 年至 2008 年间出生的胎龄≤35 周的婴儿。
观察指标
比较双胞胎和三胞胎妊娠与单胎妊娠发生 1 个后代 PVL 的风险。
结果
在 6195 名婴儿中，有 117 名单胎和 39 名多胎被诊断为囊性 PVL。围产期数据、超声表现和神经发育结局均无差异。36 周前出生的双胞胎妊娠中至少有 1 名婴儿发生 PVL 的相对风险（RR）为 2.181（95%CI 1.474-3.228，p<0.0001），三胞胎妊娠为 6.793（95%CI 2.470-13.108，p<0.0001）。受影响的双胞胎中有 3%是通过体外受精受孕的，而三胞胎中有 100%是通过体外受精受孕的（p<0.001）。
结论
我们发现，早产儿的双胞胎和三胞胎妊娠发生 PVL 的风险增加。
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