D2 多巴胺受体基因单核苷酸多态性在重度抑郁症及抗抑郁治疗反应中的作用。
The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment.
机构信息
The Psychiatric Laboratory & the Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
出版信息
Psychiatry Res. 2012 Dec 30;200(2-3):1047-50. doi: 10.1016/j.psychres.2012.06.024. Epub 2012 Jul 15.
Abstract
The study analyzed the effect of dopamine 2 receptor gene (DRD2) polymorphism on the risk for major depressive disorder (MDD) and the response to selective serotonin reuptake inhibitors (SSRIs). The results suggest that the DRD2 gene may play a role on MDD susceptibility and the onset-time of antidepressant response.
摘要
该研究分析了多巴胺 2 受体基因（DRD2）多态性对重度抑郁症（MDD）发病风险和对选择性 5-羟色胺再摄取抑制剂（SSRIs）反应的影响。结果表明，DRD2 基因可能在 MDD 易感性和抗抑郁药反应的发病时间上发挥作用。
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