日本产超广谱β-内酰胺酶大肠埃希菌的分子特征：CTX-M-15 产大肠埃希菌 ST131 的出现。
Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli in Japan: emergence of CTX-M-15-producing E. coli ST131.
机构信息
Department of Infection Control and Laboratory Diagnostics, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
出版信息
Diagn Microbiol Infect Dis. 2012 Oct;74(2):201-3. doi: 10.1016/j.diagmicrobio.2012.06.011. Epub 2012 Jul 12.
We investigated the molecular characteristics of ESBL-producing Escherichia coli in Japan. A total of 101 clinical isolates of ESBL-positive E. coli collected in Japan between June 2008 and November 2009 were studied. Among the 101 strains, 97 were positive for CTX-M, while 47 and two were positive for TEM and SHV, respectively. Sequencing revealed that CTX-M-14 was most common (49/101), followed by CTX-M-27 (22/101) and CTX-M-15 (8/101). Based on MLST data, seven of eight CTX-M-15 producers belonged to ST131. This is the first report about clinical isolates of E. coli ST131 possessing CTX-M-15 in Japan.
我们研究了日本产 ESBL 大肠杆菌的分子特征。我们研究了 2008 年 6 月至 2009 年 11 月期间在日本收集的 101 株 ESBL 阳性大肠杆菌的临床分离株。在 101 株菌株中，97 株为 CTX-M 阳性，47 株和 2 株分别为 TEM 和 SHV 阳性。测序结果显示，CTX-M-14 最为常见（49/101），其次是 CTX-M-27（22/101）和 CTX-M-15（8/101）。根据 MLST 数据，8 株 CTX-M-15 生产者中有 7 株属于 ST131。这是日本首次报告大肠杆菌 ST131 临床分离株携带 CTX-M-15。
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