Department of Pathology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Clin Chim Acta. 2012 Nov 12;413(21-22):1753-60. doi: 10.1016/j.cca.2012.07.003. Epub 2012 Jul 13.
Dickkopf-1 (DKK1), a secreted protein known as a negative regulator of the Wnt signaling pathway, has been implicated in tumorigenesis. However, the clinical significance of DKK1 in gastric cancer has not been clarified.
Serum concentrations of DKK1 in 153 patients with gastric cancer and 173 healthy controls were assessed. For tissue DKK1, immunohistochemistry was performed in 144 cancer specimens from 153 patients and in an additional 265 consecutive gastric cancer specimens.
The serum DKK1 concentrations were significantly higher in the gastric cancer patients than in the healthy controls (p<0.001). At a cutoff concentration of 31.9150 pg/ml, the sensitivity and the specificity for gastric cancer diagnosis were 87.6% and 87.9%, respectively. The gastric cancer patients with a serum DKK1 level of ≥ 60.0 pg/ml had significantly diminished survival compared with the patients whose serum DKK1 levels were lower (p=0.033). The DKK1 overexpression in the cancer specimens significantly correlated with the increased serum DKK1 concentrations.
Serum DKK1 levels have the potential as a diagnostic marker at a low cutoff value and as a prognostic marker at a high cutoff value. Serum and tissue DKK1 levels may aid in diagnosing gastric cancer and predicting patient outcomes.
Dickkopf-1（DKK1）是一种已知的 Wnt 信号通路负调节剂的分泌蛋白，与肿瘤发生有关。然而，DKK1 在胃癌中的临床意义尚未阐明。
评估了 153 例胃癌患者和 173 例健康对照者血清中 DKK1 的浓度。对于组织 DKK1，对 153 例患者的 144 例癌症标本和另外 265 例连续胃癌标本进行了免疫组织化学检测。
胃癌患者血清 DKK1 浓度明显高于健康对照组（p<0.001）。在 31.9150pg/ml 的截断浓度下，用于诊断胃癌的敏感性和特异性分别为 87.6%和 87.9%。血清 DKK1 水平≥60.0pg/ml 的胃癌患者的生存时间明显短于血清 DKK1 水平较低的患者（p=0.033）。癌症标本中 DKK1 的过表达与血清 DKK1 浓度的升高显著相关。
血清 DKK1 水平在低截断值时具有作为诊断标志物的潜力，在高截断值时具有作为预后标志物的潜力。血清和组织 DKK1 水平可能有助于诊断胃癌和预测患者的预后。
