State Key Laboratory of Bioactive Substance and Function of NaturalMedicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
Fitoterapia. 2012 Oct;83(7):1184-90. doi: 10.1016/j.fitote.2012.07.002. Epub 2012 Jul 14.
Three new triterpenoid saponins polygalasaponins LI-LIII (1-3) with two acylation groups in oligosaccharide chain, together with three known saponins were isolated from the roots of Polygala japonica Houtt. (4-6). The neuroprotective effects of these compounds on neuron-like PC12 cells were evaluated in vitro. Compounds 5 and 6 show neuroprotective effects in Aβ₂₅₋₃₅ model at the concentration of 10 μM.
远志糖苷 LI-LIII（1-3），它们在寡糖链中有两个酰化基团，以及三种已知的皂苷（4-6）。这些化合物在体外对神经元样 PC12 细胞的神经保护作用进行了评估。在 10 μM 的浓度下，化合物 5 和 6 在 Aβ₂₅₋₃₅ 模型中表现出神经保护作用。
