Xu Si-cheng, Kuang Jiang-ying, Liu Jin, Ma Chun-lan, Feng Yu-lin, Su Zhi-guang
Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
Acta Pharmacol Sin. 2012 Aug;33(8):998-1003. doi: 10.1038/aps.2012.69. Epub 2012 Jul 16.
Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the association between FGF7 polymorphisms with COPD susceptibility in a Chinese Han population.
We conducted a case-control study of 279 COPD patients and 367 age- and gender-distribution-matched control subjects. The tagging SNPs rs10519225 and rs7170426 in FGF7 were genotyped by SNaPshot. The associations of each SNP genotype and haplotype constructed by these loci with COPD were analyzed.
A multivariate analysis showed that rs10519225 was significantly associated with an increased risk of COPD (P=0.011, OR=1.535, FDR q=0.022), whereas no association was found for rs7170426. Linkage disequilibrium (LD) analysis showed that these loci were in weak LD, with an r(2) of 0.033 and a D' of 0.232 (95% CI: 0.150-0.520). The haplotype constructed by allele G at rs10519225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P=0.012, OR=0.751, FDR q=0.048).
These findings suggest that FGF7 may be one susceptibility factor for COPD.
成纤维细胞生长因子7（FGF7）参与包括肺部疾病在内的多种生理和病理过程。然而，关于FGF7基因多态性对慢性阻塞性肺疾病（COPD）易感性的影响，人们了解相对较少。本研究旨在探讨中国汉族人群中FGF7基因多态性与COPD易感性之间的关联。
我们对279例COPD患者和367例年龄及性别分布匹配的对照者进行了病例对照研究。通过SNaPshot对FGF7中的标签单核苷酸多态性（SNP）rs10519225和rs7170426进行基因分型。分析了每个SNP基因型以及由这些位点构建的单倍型与COPD的关联。
多因素分析显示，rs10519225与COPD风险增加显著相关（P = 0.011，比值比[OR]=1.535，错误发现率[FDR] q = 0.022），而rs7170426未发现关联。连锁不平衡（LD）分析表明，这些位点处于弱LD状态，r²为0.033，D'为0.232（95%置信区间：0.150 - 0.520）。由rs10519225处的等位基因G和rs7170426处的等位基因A构建的单倍型与COPD易感性降低相关（P = 0.012，OR = 0.751，FDR q = 0.048）。
这些发现提示FGF7可能是COPD的一个易感因素。
