Limson B M, Chan V F, Guzman S V, Maaba M R, Mendoza M T
J Infect Dis. 1979 Sep;140(3):415-8. doi: 10.1093/infdis/140.3.415.
The pathogenesis of rheumatic fever has been linked to various immune mechanisms involving streptococcal antibodies and heart tissue antigens. Latent myocarditis due to group B coxsackievirus has also been considered as a possible conditioning factor. The validity of the role of infection with group B coxsackievirus in rheumatic fever was tested by determining the incidence of type-specific neutralizing antibodies in sera of Filipino children. Analysis of the results by means of a normal Z-test showed that the incidence in rheumatic children was not statistically significant in comparison to the incidence in asymptomatic children.
风湿热的发病机制与涉及链球菌抗体和心脏组织抗原的多种免疫机制有关。B组柯萨奇病毒引起的潜在性心肌炎也被认为是一个可能的诱发因素。通过测定菲律宾儿童血清中型特异性中和抗体的发生率，对B组柯萨奇病毒感染在风湿热中作用的有效性进行了测试。采用常规Z检验对结果进行分析，结果显示，与无症状儿童的发生率相比，风湿热儿童的发生率在统计学上无显著差异。
