Pattanayak Mohanty Sweta, Ray Jay Gopal, Mukherjee Sanjit, Mandal Chitra, Chaudhuri Keya
Department of Oral Pathology, Dr R Ahmed Dental College and Hospital, Kolkata, India.
BMJ Case Rep. 2010 Nov 23;2010:bcr0120102645. doi: 10.1136/bcr.01.2010.2645.
Melanotic neuroectodermal tumour of infancy (MNTI) is a rare benign tumour of neural crest origin that was first described by Krompecher in 1918.1 It is predominantly found in infancy, with about 92% of cases below the age of 12 months and 82% below the age of 6 months. The predominant site of origin is in the premaxilla though it is reported at other sites also including the skull, the mandible, the epididymis and the brain.2 The lesions often have areas of bluish discolouration on the surface and are characterised by displacement of the involved tooth bud and local aggressiveness. The present report deals with two cases of MNTI, a 5-month-old baby girl and a 6-month-old baby boy who reported to the Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College and Hospital, Kolkata, India. The clinical, radiological, histological and immunohistochemical findings, confirmed the diagnosis of MNTI. Flow cytometry was performed to analyse aneuploidy. The tumours were treated surgically with no history of recurrence to date.
婴儿黑色素性神经外胚层肿瘤（MNTI）是一种罕见的起源于神经嵴的良性肿瘤，由克伦佩彻于1918年首次描述。它主要发生于婴儿期，约92%的病例在12个月以下，82%在6个月以下。主要起源部位是上颌前部，不过也有报道称在其他部位出现，包括颅骨、下颌骨、附睾和脑。这些病变表面常有 bluish 变色区域，其特征是受累牙胚移位和局部侵袭性。本报告涉及两例MNTI病例，一名5个月大的女婴和一名6个月大的男婴，他们前往印度加尔各答R·艾哈迈德牙科学院及医院口腔颌面病理学系就诊。临床、放射学、组织学和免疫组化检查结果确诊为MNTI。进行了流式细胞术分析非整倍体情况。肿瘤通过手术治疗，至今无复发史。
