β-硒代胺对大鼠脑和肝脂质过氧化的抗氧化特性。
Antioxidant properties of β-seleno amines against lipid peroxidation in rat brain and liver.
机构信息
Department of Eastern Medicine and Surgery, University of the Pooch Rawalakot Azad Kashmir Pakistan.
Department of Chemistry, Abdul Wali Khan University Mardan, Khyber pakhtunkhwa, Pakistan.
出版信息
Environ Toxicol Pharmacol. 2012 Sep;34(2):446-453. doi: 10.1016/j.etap.2012.06.002. Epub 2012 Jun 26.
β-Seleno amines were screened for in vitro antioxidant activity. The compounds (C1-C4) were tested against lipid peroxidation induced by iron and sodium nitroprusside in rat brain and liver homogenates. The compounds showed inhibition against thiobarbituric acid reactive species (TBARS) induced by different pro-oxidants (10μM FeSO(4) and 5μM sodium nitroprusside (SNP) in rat brain and liver homogenates. The compounds exhibited strong antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and phosphomolybdenum assays. The IC(50) values revealed that the β-seleno amines in which the amino group was protected with protecting groups tert-butyloxycarbonyl (Boc) and Tosyl (Ts) groups showed better antioxidant profiles compared to the free monoselenides. The total antioxidant activity of C1, C2, C3 and C4 were found to be 85.2±11.5, 114±7.9, 138±8.5, 125.81±5.2μM/ml of ascorbic acid respectively. Therefore, these compounds may be used as synthetic antioxidants.
β-硒代胺被筛选用于体外抗氧化活性研究。这些化合物（C1-C4）在大鼠脑和肝匀浆中，被测试其对铁和亚硝酰基铁氰化钠诱导的脂质过氧化的抑制作用。这些化合物在不同的促氧化剂（10μM 的 FeSO4 和 5μM 的亚硝酰基铁氰化钠（SNP））诱导的大鼠脑和肝匀浆中的硫代巴比妥酸反应性物质（TBARS）中表现出抑制作用。这些化合物在 2,2-二苯基-1-苦基肼基（DPPH）自由基和磷钼酸盐测定中表现出很强的抗氧化活性。IC50 值表明，与游离的单硒化物相比，氨基被叔丁氧羰基（Boc）和对甲苯磺酰基（Ts）保护基保护的β-硒代胺具有更好的抗氧化特性。C1、C2、C3 和 C4 的总抗氧化活性分别为 85.2±11.5、114±7.9、138±8.5、125.81±5.2μM/ml 的抗坏血酸。因此，这些化合物可用作合成抗氧化剂。
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