Ohtsubo Koushiro, Watanabe Hiroyuki, Mouri Hisatsugu, Yamashita Kaname, Yasumoto Kazuo, Yano Seiji
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
JOP. 2012 Jul 10;13(4):420-6. doi: 10.6092/1590-8577/749.
Pancreatic cancer is often complicated with upper gastrointestinal lesions. However, there have been few endoscopic studies in pancreatic cancer patients. We retrospectively investigated the upper gastrointestinal lesions in patients with pancreatic cancer who underwent upper gastrointestinal endoscopy.
Upper gastrointestinal endoscopy was performed in 75 patients with pancreatic cancer between 2003 and 2010. We examined upper gastrointestinal lesions, such as gastroduodenal invasion, ulcers, esophagogastric varices, radiation-induced gastroduodenal mucosal lesions, and portal hypertensive gastropathy.
Among the 53 patients with pancreatic cancer who underwent upper gastrointestinal endoscopy at diagnosis, 23 gastrointestinal lesions were observed in 20 patients (38%) as follows: gastroduodenal invasion (n=11), esophagogastric varices (n=7), gastroduodenal ulcers (n=3), portal hypertensive gastropathy (n=1) and duodenal metastasis (n=1). Among the 75 patients with pancreatic cancer, 56 gastrointestinal lesions were identified in 46 patients (61%) during the clinical course as follows: gastroduodenal invasion (n=20), esophagogastric varices (n=14), radiation-induced gastroduodenal mucosal lesions (n=9), gastroduodenal ulcers (except radiation-induced ulcers) (n=8), portal hypertensive gastropathy (n=3), duodenal metastasis (n=1), and gastrointestinal bleeding from unknown primary site (n=1). Twenty-nine (52%) of the 56 gastrointestinal lesions showed symptoms related to the lesions. Fifteen (27%) lesions were accompanied by upper gastrointestinal bleeding. Fourteen (25%) lesions developed according to the progression of pancreatic cancer.
We should pay attention to upper gastrointestinal lesions in patients with pancreatic cancer.
胰腺癌常合并上消化道病变。然而，针对胰腺癌患者的内镜研究较少。我们回顾性调查了接受上消化道内镜检查的胰腺癌患者的上消化道病变情况。
2003年至2010年间，对75例胰腺癌患者进行了上消化道内镜检查。我们检查了上消化道病变，如胃十二指肠侵犯、溃疡、食管胃静脉曲张、放射性胃十二指肠黏膜病变和门静脉高压性胃病。
在53例诊断时接受上消化道内镜检查的胰腺癌患者中，20例患者（38%）发现了23处胃肠道病变，具体如下：胃十二指肠侵犯（n = 11）、食管胃静脉曲张（n = 7）、胃十二指肠溃疡（n = 3）、门静脉高压性胃病（n = 1）和十二指肠转移（n = 1）。在75例胰腺癌患者中，46例患者（61%）在临床病程中发现了56处胃肠道病变，具体如下：胃十二指肠侵犯（n = 20）、食管胃静脉曲张（n = 十四）、放射性胃十二指肠黏膜病变（n = 9）、胃十二指肠溃疡（不包括放射性溃疡）（n = 8）、门静脉高压性胃病（n = 3）、十二指肠转移（n = 1）和不明原发部位的胃肠道出血（n = one）。56处胃肠道病变中有29处（52%）出现了与病变相关的症状。15处（27%）病变伴有上消化道出血。14处（25%）病变随胰腺癌的进展而出现。
我们应关注胰腺癌患者的上消化道病变。
