Zhao L, Zhao Y, Bao Q, Niess H, Jauch K-W, Bruns C J
Department of Surgery, Munich Medical Center, Campus Grosshadern, LMU Munich, Munich, Germany.
Eur Surg Res. 2012;49(1):8-15. doi: 10.1159/000339610. Epub 2012 Jul 11.
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer therapies in the future. CSCs typically only constitute a small fraction of the total tumor burden; however, they harbor self-renewal capacity and appear to be relatively resistant to conventional therapies. Recent therapeutic approaches aim to eliminate or differentiate CSCs or to disrupt the niches in which they reside. Better understanding of the biological characteristics of CSCs as well as improved preclinical and clinical trials targeting CSCs may revolutionize the treatment of many cancers.
癌症干细胞（CSCs）的存在正受到越来越多的关注，特别是因其具有进入临床常规治疗的潜在能力。CSC领域的快速进展为未来开发更可靠的抗癌疗法提供了证据。CSCs通常仅占肿瘤总负荷的一小部分；然而，它们具有自我更新能力，并且似乎对传统疗法相对耐药。最近的治疗方法旨在消除或分化CSCs，或破坏它们所处的微环境。更好地了解CSCs的生物学特性以及针对CSCs改进的临床前和临床试验可能会彻底改变许多癌症的治疗方式。
