Bandyopadhyay A, Deadhikari H, Ranjit M, Bhattacharyya S P
Department of Zoology, University of Kalyani, India.
Indian J Exp Biol. 1990 Oct;28(10):915-9.
Adrenocortical influence on uropygial gland of 10-day old male white leghorn chicken was assessed by suppressing glucocorticoid level with metyrapone and following corticosterone and deoxycorticosterone acetate (DOC) treatments (im), 100 micrograms each on alternate day for a period of 15 days. Metyrapone treatment resulted in significant atrophy of the uropygial gland with a severe regression of the glandular alveoli due to cytopycnosis, cellular disintegration and drastic cell loss. Concomitantly, there was a depletion of glandular lipid and its diester wax fraction. Corticosterone, administered simultaneously with metyrapone, counteracted severe adverse effects of the latter on the uropygial gland. In the normal chicken also corticosterone alone caused glandular hypertrophy with increased rate of cell renewal and cell growth within the alveoli and, to a lesser extent, augmented output of the glandular lipids. Simultaneous administration of corticosterone and testosterone propionate (TP), on the other hand, caused a moderate suppressive influence on this gland. DOC treatment alone or with metyrapone and TP failed to exert any noteworthy change in the uropygial gland excepting a moderate reduction of gland weight and a rise of glandular lipids observed after combined injections of DOC with TP and with metyrapone respectively.
通过用甲吡酮抑制糖皮质激素水平，并在之后进行皮质酮和醋酸脱氧皮质酮（DOC）处理（肌肉注射），每次100微克，隔日一次，共15天，评估10日龄雄性白来航鸡肾上腺皮质对尾脂腺的影响。甲吡酮处理导致尾脂腺显著萎缩，腺泡严重退化，原因是细胞核固缩、细胞解体和大量细胞丢失。同时，腺脂质及其二酯蜡组分减少。与甲吡酮同时给予皮质酮可抵消后者对尾脂腺的严重不良影响。在正常鸡中，单独给予皮质酮也会导致腺体肥大，腺泡内细胞更新率和细胞生长增加，并且在较小程度上增加腺脂质的分泌量。另一方面，同时给予皮质酮和丙酸睾酮（TP）对该腺体有中度抑制作用。单独给予DOC或与甲吡酮和TP联合使用时，除了分别在DOC与TP以及与甲吡酮联合注射后观察到腺体重量适度减轻和腺脂质增加外，尾脂腺未出现任何显著变化。
