3-芳腙基-4-苯基-[1,2,4]三氮唑并[2,3-a]喹唑啉-2,7(1H)-二酮的合成、互变异构结构和抗菌活性。
Synthesis, tautomeric structure and antimicrobial activity of 3-arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones.
机构信息
Department of Chemistry, Faculty of Science, University of Cairo, Giza 12311, Egypt.
出版信息
Molecules. 2012 Jul 13;17(7):8483-93. doi: 10.3390/molecules17078483.
A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl-[1,2,4]triazepino[2,3-H]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
描述了一种合成 hitherto unreported 3-arylazo-4-phenyl-[1,2,4]triazepino[2,3-H]quinazoline-2,7(1H)-diones 的简单策略。光谱数据表明，所研究的化合物主要以腙互变异构体形式存在。还评估了新合成化合物的抗菌活性。结果表明，这些化合物中的一些对细菌具有中等活性。
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