Deng Jian, Zou Jie-Xin, Zhou Xian-Min, Wu Zhong-Dao
Department of Parasitology, Medical College of Nanchang University, Nanchang, 330006, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012 Apr;24(2):228-31.
Angiostrongylus cantonensis is a lung worm of rat (definitive host). Human, an abnormal host, can acquire the infection by ingesting food containing the infective larvae of this worm (third-stage larvae). Although the larvae cannot develop into adult worm in human body, it moves to human brain and eyes, causing eosinophilic meningitis (EM), meningoencephalitis, or ocular angiostrongyliasis (OA). Here we review papers related to Angiostrongylus cantonensis and angiostrongyliasis cantonensis which were published in recent ten years, and identify the main institutes and principal investigators (PI) who are researching Angiostrongylus cantonensis. We also outline the advances in research on pathogen biology, pathogenesis, diagnostic techniques, epidemiology and prevention, as well as drug developed against Angiostrongylus cantonensis.
广州管圆线虫是大鼠(终宿主)的一种肺线虫。人类作为异常宿主,可通过摄入含有该线虫感染性幼虫(第三期幼虫)的食物而感染。尽管幼虫在人体中无法发育为成虫,但它会迁移至人脑和眼睛,引发嗜酸性粒细胞性脑膜炎(EM)、脑膜脑炎或眼部管圆线虫病(OA)。在此,我们综述了近十年发表的与广州管圆线虫和广州管圆线虫病相关的论文,并确定了研究广州管圆线虫的主要机构和主要研究者(PI)。我们还概述了病原体生物学、发病机制、诊断技术、流行病学与预防以及针对广州管圆线虫研发的药物等方面的研究进展。