Chan Huasheng, Pitson Stuart M
Molecular Signalling Laboratory, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
Biochim Biophys Acta. 2013 Jan;1831(1):147-56. doi: 10.1016/j.bbalip.2012.07.005. Epub 2012 Jul 16.
Sphingosine kinases (SKs) catalyse the conversion of sphingosine to sphingosine 1-phosphate (S1P), a signalling lipid that is involved in a plethora of cellular processes including proliferation, apoptosis, calcium homeostasis, angiogenesis, vascular and neuronal maturation, cell migration and immune responses. Over the last few years, it has become clear that SKs are subject to various forms of post-translational regulation which play important roles in the function of these enzymes. Moreover, dysregulation of SKs has been implicated in many pathological conditions, such as cancer. Here we review the various mechanisms of post-translational regulation of the SKs with the view that such knowledge may lead to the development of therapeutic strategies to modulate the activities of these enzymes in the treatment of cancer and a range of other conditions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
鞘氨醇激酶（SKs）催化鞘氨醇转化为1-磷酸鞘氨醇（S1P），这是一种信号脂质，参与众多细胞过程，包括增殖、凋亡、钙稳态、血管生成、血管和神经元成熟、细胞迁移以及免疫反应。在过去几年中，已明确SKs受到多种形式的翻译后调控，这些调控在这些酶的功能中发挥重要作用。此外，SKs的失调与许多病理状况有关，如癌症。在此，我们综述SKs翻译后调控的各种机制，认为此类知识可能会促成开发治疗策略，以调节这些酶的活性，用于治疗癌症和一系列其他病症。本文是名为“溶血磷脂研究进展”的特刊的一部分。
