Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45237, USA.
Mol Psychiatry. 2013 Jun;18(6):646-55. doi: 10.1038/mp.2012.101. Epub 2012 Jul 17.
Resiliency to the adverse effects of extraordinary emotional trauma on the brain varies within the human population. Accordingly, some people cope better than others with traumatic stress. Neuropeptide Y (NPY) is a 36-amino-acid peptide transmitter abundantly expressed in forebrain limbic and brain stem areas that regulate stress and emotional behaviors. Studies largely in rodents demonstrate a role for NPY in promoting coping with stress. Moreover, accruing data from the genetic to the physiological implicate NPY as a potential 'resilience-to-stress' factor in humans. Here, we consolidate findings from preclinical and clinical studies of NPY that are of relevance to stress-associated syndromes, most prototypically posttraumatic stress disorder (PTSD). Collectively, these data suggest that reduced central nervous system (CNS) NPY concentrations or function may be associated with PTSD. We also link specific symptoms of human PTSD with extant findings in the NPY field to reveal potential physiological contributions of the neuropeptide to the disorder. In pursuit of understanding the physiological basis and treatment of PTSD, the NPY system is an attractive target.
人类个体对于极端情绪创伤的大脑负面影响的适应能力存在差异。因此，有些人比其他人更能应对创伤后应激。神经肽 Y（NPY）是一种 36 个氨基酸的肽递质，在大脑前脑边缘和脑干区域大量表达，调节应激和情绪行为。研究主要在啮齿动物中表明，NPY 在促进应对压力方面发挥作用。此外，从遗传到生理的累积数据表明，NPY 是人类应激相关综合征（最典型的创伤后应激障碍）的潜在“应激适应”因素。在这里，我们整合了与应激相关综合征（最典型的创伤后应激障碍）相关的 NPY 的临床前和临床研究结果。这些数据表明，中枢神经系统（CNS）NPY 浓度或功能降低可能与 PTSD 有关。我们还将人类 PTSD 的特定症状与 NPY 领域的现有发现联系起来，以揭示该神经肽对该疾病的潜在生理贡献。为了了解 PTSD 的生理基础和治疗方法，NPY 系统是一个有吸引力的目标。
