参战退伍军人的血浆神经肽Y浓度：与创伤暴露、创伤后应激障碍的恢复及应对方式的关系
Plasma neuropeptide Y concentrations in combat exposed veterans: relationship to trauma exposure, recovery from PTSD, and coping.
作者信息
Yehuda Rachel, Brand Sarah, Yang Ren-Kui
机构信息
Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, and the Bronx Veterans Affairs Medical Center, New York, New York 10468, USA.
出版信息
Biol Psychiatry. 2006 Apr 1;59(7):660-3. doi: 10.1016/j.biopsych.2005.08.027. Epub 2005 Dec 1.
BACKGROUND
There is emerging interest in examining the role of plasma neuropeptide Y (NPY) as a protective stress factor.
METHODS
To further investigate this possibility, plasma NPY was measured in 11 nonexposed veterans, 11 combat-exposed veterans without posttraumatic stress disorder (PTSD), and 12 veterans with current PTSD.
RESULTS
A significant group difference in plasma NPY (F(2,31) = 5.16, p = .012) was observed, reflecting higher NPY levels in exposed veterans without PTSD than in nonexposed but comparable levels in veterans with current PTSD. Among those without current PTSD, veterans with past PTSD had higher NPY levels than those without past PTSD (t(9) = 2.71, p = .024). After controlling for all other variables, NPY levels were significantly predicted by extent of symptom improvement and lower combat exposure and significant at a trend level with positive coping.
CONCLUSIONS
Plasma NPY levels may represent a biologic correlate of resilience to or recovery from the adverse effects of stress.
背景
人们对研究血浆神经肽Y（NPY）作为一种保护性应激因子的作用的兴趣日益浓厚。
方法
为进一步探究这种可能性，对11名未接触过战斗的退伍军人、11名接触过战斗但无创伤后应激障碍（PTSD）的退伍军人以及12名患有当前PTSD的退伍军人的血浆NPY进行了测量。
结果
观察到血浆NPY存在显著的组间差异（F(2,31) = 5.16，p = .012），这表明未患PTSD的接触过战斗的退伍军人的NPY水平高于未接触过战斗的退伍军人，但与患有当前PTSD的退伍军人的水平相当。在那些当前未患PTSD的人中，有过PTSD病史的退伍军人的NPY水平高于没有PTSD病史的退伍军人（t(9) = 2.71，p = .024）。在控制了所有其他变量后，NPY水平可由症状改善程度、较低的战斗接触程度显著预测，并且在趋势水平上与积极应对显著相关。
结论
血浆NPY水平可能代表对应激不良反应的恢复力或恢复的生物学相关指标。
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