基于麻黄碱的二硒化物：一种混杂的催化剂，适合模拟酶谷胱甘肽过氧化物酶（GPx）并促进对映选择性 C-C 偶联反应。
Ephedrine-based diselenide: a promiscuous catalyst suitable to mimic the enzyme glutathione peroxidase (GPx) and to promote enantioselective C-C coupling reactions.
机构信息
NanoBio, Dpto de Química, CCNE, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
出版信息
Org Biomol Chem. 2012 Aug 28;10(32):6595-9. doi: 10.1039/c2ob25539a. Epub 2012 Jul 17.
PMID:22801447
Abstract
The ephedrine-based diselenide appears as a new promiscuous catalyst, able to generate optically active alcohols by addition of organozinc to aldehydes (up to 97% ee), and shows powerful GPx like activity, reducing H(2)O(2) to water in only 16.33 min (eleven times faster than PhSeSePh).
摘要
基于麻黄碱的二硒化物似乎是一种新的杂化催化剂，能够通过有机锌与醛的加成反应生成具有光学活性的醇（高达 97%ee），并且表现出强大的 GPx 样活性，将 H(2)O(2)还原为水仅需 16.33 分钟（比 PhSeSePh 快 11 倍）。
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