Suvatte V, Issaragrisil S, Chandanayingyong D, Mahasandana C, Tanphaichitr V S, Jirapinyo P
Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1990 Oct;73(10):572-80.
Massive chemotherapy and autologous bone marrow transplantation (ABMT) have been successfully used for the treatment of Burkitt's lymphoma. We report our first success with such treatment in two children with Burkitt's lymphoma in Thailand. Both patients had massive abdominal tumors with ascites and minimal bone marrow metastasis at the first presentation. They received induction chemotherapy and intensive treatment including central nervous system prophylaxis with cranial irradiation and intrathecal methotrexate until being in complete remission before starting massive chemotherapy, comprising the combination of BCNU, cytosine arabinoside, cyclophosphamide and 6-thioguanine followed by ABMT. Both patients recovered completely following intensive supportive treatments post ABMT and are still good health without evidence of the disease for 18 and 8 months after transplantation respectively. The role of massive chemotherapy and ABMT for the treatment of non-Hodgkin's lymphoma especially Burkitt's lymphoma was discussed.
大剂量化疗和自体骨髓移植（ABMT）已成功用于治疗伯基特淋巴瘤。我们报告了在泰国对两名伯基特淋巴瘤患儿进行此类治疗的首例成功案例。两名患者初诊时均有巨大腹部肿瘤伴腹水，骨髓转移极少。他们接受了诱导化疗和强化治疗，包括采用颅脑照射和鞘内注射甲氨蝶呤进行中枢神经系统预防，直至完全缓解后开始大剂量化疗，化疗方案为卡莫司汀、阿糖胞苷、环磷酰胺和6-硫鸟嘌呤联合应用，随后进行ABMT。两名患者在ABMT后经过强化支持治疗均完全康复，分别在移植后18个月和8个月仍健康良好，无疾病迹象。文中讨论了大剂量化疗和ABMT在治疗非霍奇金淋巴瘤尤其是伯基特淋巴瘤中的作用。
