甲状腺髓样癌脑转移
Brain metastasis from medullary thyroid carcinoma.
作者信息
Börcek P, Asa S L, Gentili F, Ezzat S, Kiehl T-R
机构信息
Department of Pathology, Batman Regional State Hospital, Batman, Turkey.
出版信息
BMJ Case Rep. 2010 Dec 29;2010:bcr0920103301. doi: 10.1136/bcr.09.2010.3301.
Abstract
The brain is an exceedingly rare site of metastasis in medullary thyroid carcinoma (MTC). A 50-year-old female who had a history of micro-MTC 11 years prior developed a cerebellar metastasis which was incidentally discovered. Imaging revealed a right cerebellar hemispheric mass with contrast enhancement on CT scans. Histopathologic exam demonstrated a metastatic tumour composed of nodules and sheets of large tumour cells with abundant cytoplasm. Immunohistochemistry confirmed the origin from a MTC. This case report highlights the unique features of an unusual metastatic brain tumour, which followed an indolent course for a long time despite multiple distant metastases.
摘要
在甲状腺髓样癌（MTC）中，脑转移极为罕见。一名50岁女性，11年前有微小MTC病史，偶然发现发生了小脑转移。影像学检查显示，CT扫描上右侧小脑半球有一肿块并伴有强化。组织病理学检查显示，转移瘤由大肿瘤细胞结节和片块组成，肿瘤细胞胞质丰富。免疫组化证实其起源于MTC。本病例报告突出了这一不寻常的转移性脑肿瘤的独特特征，尽管已有多处远处转移，但病程长期呈惰性。
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