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在医源性股动脉损伤情况下,将凝血酶直接超声引导注射到假性动脉瘤腔内作为一种治疗方法的个人经验。

Personal experiences in direct ultrasound-guided injection of thrombin into the lumen of pseudoaneurysm as a method of treatment in case of iatrogenic femoral artery damage.

作者信息

Słonina Joanna, Obremska Marta, Zaleska-Dorobisz Urszula, Agrawal Anil, Malczewska Joanna, Koźmińska Urszula, Sąsiadek Marek

机构信息

Department of Radiology, Wrocław Medical University, Wrocław, Poland.

出版信息

Pol J Radiol. 2010 Apr;75(2):33-7.

PMID:22802774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3389867/
Abstract

BACKGROUND

Pseudoaneurysms constitute a quite common complication of procedures requiring puncture of the common femoral artery. The risk factors of the condition include: obesity, arterial hypertension, sex (more prevalent in males) as well as antithrombotic therapy.

MATERIAL/METHODS: The US-guided injection of thrombin into the pseudoaneurysm lumen was performed in patients referred from the Department of Invasive Cardiology who had undergone coronarography or coronary angioplasty. Pseudoaneurysms constituted the complication of common femoral artery canulation. After setting the diagnosis of pseudoaneurysm by means of Doppler ultrasound, patients with large pseudoaneurysms of volume exceeding 10 mm were qualified for thrombin injection. Generally, 33 patients underwent the treatment. In 3 cases - due to the presence of multiocular pseudoaneurysm - thrombin was administered twice.

RESULTS

Taking into account the safety of the procedure, ultimately 33 patients were qualified for thrombin administration, in whom aneurism of diameter exceeding 10 mm was diagnosed. In 3 patients with aneurysm of less than 10mm, only a compression band was used prophylactically. In one case, because of a considerable oedema surrounding the tissue, as well as deep location of the aneurysm in the groin, thrombin treatment was not given due to technical reasons. In 30 cases, single administration of thrombin was effective and resulted in a complete thrombosis of the pseudoaneurism lumen within a couple of seconds following thrombin injection. In 3 patients with multicellular aneurysm, thrombin was given twice, resulting in a total obliteration of the pseudoaneurysm in two cases only. No complications were observed after the performed procedures. No recanalisation of pseudoaneurysms was demonstrated in follow-up examinations.

CONCLUSIONS

  1. Direct thrombin injection into the pseudoaneurysm lumen can constitute an alternative method of treatment for open surgical techniques. 2. The procedure is highly effective, cheap and minimally invasive.
摘要

背景

假性动脉瘤是需要穿刺股总动脉的手术中相当常见的并发症。该病症的风险因素包括:肥胖、动脉高血压、性别(男性更为普遍)以及抗血栓治疗。

材料/方法:对来自介入心脏病科、接受过冠状动脉造影或冠状动脉成形术的患者,在超声引导下将凝血酶注入假性动脉瘤腔内。假性动脉瘤是股总动脉插管的并发症。通过多普勒超声确诊假性动脉瘤后,体积超过10毫米的大型假性动脉瘤患者符合凝血酶注射条件。一般来说,33例患者接受了治疗。3例患者由于存在多腔假性动脉瘤,凝血酶注射了两次。

结果

考虑到手术的安全性,最终33例被诊断为直径超过10毫米动脉瘤的患者符合凝血酶给药条件。3例动脉瘤小于10毫米的患者仅预防性地使用了压迫带。1例患者由于组织周围有相当程度的水肿,且动脉瘤在腹股沟处位置较深,因技术原因未进行凝血酶治疗。30例患者单次注射凝血酶有效,凝血酶注射后几秒钟内假性动脉瘤腔完全血栓形成。3例多腔动脉瘤患者凝血酶注射了两次,仅2例患者的假性动脉瘤完全闭塞。手术后未观察到并发症。随访检查未发现假性动脉瘤再通。

结论

  1. 直接将凝血酶注入假性动脉瘤腔可作为开放手术技术的替代治疗方法。2. 该手术高效、廉价且微创。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/666defde5e02/poljradiol-75-2-33-g002B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/6d716c22b1f7/poljradiol-75-2-33-g001A.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/bdfd25d8f65d/poljradiol-75-2-33-g001B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/21f87866bcdf/poljradiol-75-2-33-g002A.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/666defde5e02/poljradiol-75-2-33-g002B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/6d716c22b1f7/poljradiol-75-2-33-g001A.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/bdfd25d8f65d/poljradiol-75-2-33-g001B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/21f87866bcdf/poljradiol-75-2-33-g002A.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb8/3389867/666defde5e02/poljradiol-75-2-33-g002B.jpg

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本文引用的文献

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