儿茶酚胺、α-和β-肾上腺素能受体并不负责交感神经刺激所诱导的十二指肠运动激活。

Catecholamines, α-, and β-adrenoceptors are not responsible for activation of duodenum motility induced by sympathetic nerve stimulation.

作者信息

Sveshnikov D S, Smirnov V M, Myasnikov I L, Mongush M I, Yurasova I A

机构信息

Department of Physiology, N. I. Pirogov Russian State Medical University, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2011 Nov;152(1):5-8. doi: 10.1007/s10517-011-1438-1.

DOI:10.1007/s10517-011-1438-1

PMID:22803025

Abstract

Stimulation of sympathetic nerve in anesthetized dogs not treated with adrenergic blockers more frequently exerted stimulating rather than inhibitory effect on duodenal motility. Blockade of α- and β-adrenoceptors with phentolamine and propranolol, respectively, did not prevent the excitatory action of the sympathetic nerve stimulation, but even potentiated this effect. The data showed that catecholamines as well as α- and β-adrenoceptors are not involved in the excitatory effect of sympathetic origin.

摘要

在未用肾上腺素能阻滞剂治疗的麻醉犬中，刺激交感神经对十二指肠运动的影响更常表现为刺激作用而非抑制作用。分别用酚妥拉明和普萘洛尔阻断α和β肾上腺素能受体，并未阻止交感神经刺激的兴奋作用，反而增强了这种作用。数据表明，儿茶酚胺以及α和β肾上腺素能受体并不参与交感神经源性兴奋作用。