硫酸化纤维素衍生物可抑制凝血酶和活化因子X的活性。
Sulfated cellulose derivatives inhibit activities of thrombin and activated factor X.
作者信息
Drozd N N, Torlopov M A, Davydova A I, Makarov V A
机构信息
Laboratory of Pathology and Pharmacology of Hemostasis, Hematological Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2011 Nov;152(1):61-5. doi: 10.1007/s10517-011-1454-1.
PMID:22803041
Abstract
Sulfated derivatives based on powdered cellulose were obtained, including those containing additional (carboxymethyl, ethyl amide or phosphate) groups, and their activity against blood clotting factors (thrombin and Xa) was studied. Maximum antithrombin activity of the test compounds, measured using a coagulation test, was 144±11 U/mg.
摘要
获得了基于粉末状纤维素的硫酸化衍生物，包括含有额外（羧甲基、乙酰胺或磷酸）基团的衍生物，并研究了它们对血液凝固因子（凝血酶和Xa）的活性。使用凝血试验测定的测试化合物的最大抗凝血酶活性为144±11 U/mg。
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