Lobov G I, Pan'kova M N
Laboratory of Blood Circulation Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2012 Feb;152(4):406-8. doi: 10.1007/s10517-012-1539-5.
The effects of histamine and mechanisms of its action on the capsular smooth muscle cells of mesenteric lymph nodes were examined on isolated capsular strips under isometric conditions. Histamine (1×10(-8)-5×10(-7) M) decreased the tone of capsular smooth muscle cells and the frequency of phasic contractions. At high concentrations (more than 5×10(-6) M), histamine increased the amplitude and frequency of phasic contractions against the background of increased tonic stress. The effects of histamine were dose-dependent and were realized via direct stimulation of H(1)- and H(2)-receptors on the membrane of smooth muscle cells.
在等长条件下，对分离的肠系膜淋巴结被膜条进行实验，研究组胺对肠系膜淋巴结被膜平滑肌细胞的作用及其作用机制。组胺（1×10⁻⁸ - 5×10⁻⁷ M）可降低被膜平滑肌细胞的张力和相性收缩频率。在高浓度（超过5×10⁻⁶ M）时，组胺在紧张性张力增加的背景下增加相性收缩的幅度和频率。组胺的作用呈剂量依赖性，是通过直接刺激平滑肌细胞膜上的H₁和H₂受体实现的。
