组胺对牛肠系膜淋巴结平滑肌收缩活性的影响。

Effect of histamine on contractile activity of smooth muscles in bovine mesenteric lymph nodes.

作者信息

Lobov G I, Pan'kova M N

机构信息

Laboratory of Blood Circulation Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

出版信息

Bull Exp Biol Med. 2012 Feb;152(4):406-8. doi: 10.1007/s10517-012-1539-5.

DOI:10.1007/s10517-012-1539-5

PMID:22803097

Abstract

The effects of histamine and mechanisms of its action on the capsular smooth muscle cells of mesenteric lymph nodes were examined on isolated capsular strips under isometric conditions. Histamine (1×10(-8)-5×10(-7) M) decreased the tone of capsular smooth muscle cells and the frequency of phasic contractions. At high concentrations (more than 5×10(-6) M), histamine increased the amplitude and frequency of phasic contractions against the background of increased tonic stress. The effects of histamine were dose-dependent and were realized via direct stimulation of H(1)- and H(2)-receptors on the membrane of smooth muscle cells.

摘要

在等长条件下，对分离的肠系膜淋巴结被膜条进行实验，研究组胺对肠系膜淋巴结被膜平滑肌细胞的作用及其作用机制。组胺（1×10⁻⁸ - 5×10⁻⁷ M）可降低被膜平滑肌细胞的张力和相性收缩频率。在高浓度（超过5×10⁻⁶ M）时，组胺在紧张性张力增加的背景下增加相性收缩的幅度和频率。组胺的作用呈剂量依赖性，是通过直接刺激平滑肌细胞膜上的H₁和H₂受体实现的。