Chithra P, Chandrikha C, Kannan Arun Srinivasan, Srinath S, Srinivasan Vijaya, Jayanthi V
Department of Gastroenterology, Stanley Medical College Hospital, Chennai, India.
Trop Gastroenterol. 2012 Jan-Mar;33(1):33-8. doi: 10.7869/tg.2012.5.
Several definitions and classifications have been designed to characterize functional dyspepsia (FD), the recent one being the ROME III criteria. There have been many studies in the western population which aimed at identifying the risk factors involved in functional dyspepsia. There are fewer studies from south Asian countries.
To determine the clinical and life style variables influencing functional dyspepsia and its sub-types in patients attending a tertiary care referral centre in the Indian subcontinent.
Consecutive patients with upper gastrointestinal symptoms including, epigastric pain/burning, early satiety, postprandial fullness, heartburn and/or chest discomfort, alone or in combination, on more than 3 occasions a week, within the preceding 6 months and with a normal endoscopy were included in the study. Demographic details and the symptom profile including frequency of symptoms were recorded in a pre-structured, validated, modified proforma as per the ROME III criteria and analyzed to test the study hypothesis.
Of the 170 patients, the median age of presentation was 49 yrs and the male to female ratio was 0.62 (65:105). The mean BMI was 23.8 kg/m2. Women had a higher BMI than men. More than half of the study subjects were from the low socio-economic groups.77.6% had ulcer type symptoms and showed a decreasing trend with age. It was more common in patients with higher per capita income. Reflux type comprised of 60.6% with predominance in women. 7% had early satiety and 13.5% had postprandial fullness. Nausea and belch as an isolated (associated) phenomenon comprised of 18.8% and 17.1% respectively. None of the lifestyle variables or demographic characteristics showed a significant influence on symptom occurrence.
There was a considerable overlap of various sub-types of dyspepsia. There were no differences in life style characteristics or significant risk factors in the various subtypes of dyspepsia.
已经设计了几种定义和分类方法来描述功能性消化不良（FD），最新的是罗马Ⅲ标准。西方人群中有许多研究旨在确定功能性消化不良的相关危险因素。南亚国家的相关研究较少。
确定影响印度次大陆一家三级医疗转诊中心患者功能性消化不良及其亚型的临床和生活方式变量。
连续纳入有上消化道症状的患者，包括上腹部疼痛/烧灼感、早饱、餐后饱胀、烧心和/或胸部不适，单独或合并出现，每周超过3次，在过去6个月内且内镜检查正常。根据罗马Ⅲ标准，在预先构建、经验证的改良表格中记录人口统计学细节和症状特征，包括症状频率，并进行分析以检验研究假设。
170例患者中，就诊时的中位年龄为49岁，男女比例为0.62（65:105）。平均体重指数为23.8kg/m²。女性的体重指数高于男性。超过一半的研究对象来自社会经济地位较低的群体。77.6%有溃疡型症状，且随年龄呈下降趋势。在人均收入较高的患者中更常见。反流型占60.6%，以女性为主。7%有早饱，13.5%有餐后饱胀。恶心和嗳气作为单独（相关）现象分别占18.8%和17.1%。没有生活方式变量或人口统计学特征对症状发生有显著影响。
消化不良的各种亚型之间有相当大的重叠。消化不良的各种亚型在生活方式特征或显著危险因素方面没有差异。
