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[原发性喉淀粉样变的临床分析]

[Clinical analysis of primary laryngeal amyloidosis].

作者信息

Huang Chaoping, Tang Siquan, Zhang Jianhui, Huang Yanli, Pan Qingchun, Zhao Rui

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;26(9):389-91.

Abstract

OBJECTIVE

To analyze the clinical features and treatment protocols of primary laryngeal amyloidosis.

METHOD

Retrospective study of 5 patient hospitalized from 1996 - 2011. All of the patients by resection lesions, including four routine throat tumor resection, and burst throat by supporting laryngoscope in 1 case, all did not give lesions resection radiation and hormone therapy.

RESULT

All the 5 patients recovered clinically. There were 3 patients followed up for 0.3-7.5 years with a mean time of 3.3 years without recurrence, 2 patients lost follow-up.

CONCLUSION

Middle ages seemed to be more vulnerable. The most common disease region is true vocal cord, followed by false vocal cord, epiglottis former clearance etc. Early surgical treatment of this disease is the most important treatment, larynx endoscopic and CT for the diagnosis of great value, and pathologic biopsy especially Congo red stain positive is the basis of the specific diagnosis of this disease.

摘要

目的

分析原发性喉淀粉样变的临床特征及治疗方案。

方法

对1996年至2011年收治的5例患者进行回顾性研究。所有患者均行病变切除术,其中4例行常规喉肿物切除术,1例行支撑喉镜下肿物切除术,均未对病变进行放疗及激素治疗。

结果

5例患者均临床治愈。3例患者随访0.3 - 7.5年,平均随访时间3.3年,无复发;2例失访。

结论

中年人群似乎更易患病。最常见的病变部位是真声带,其次为假声带、会厌前间隙等。本病早期手术治疗是最重要的治疗方法,喉镜及CT对诊断有重要价值,病理活检尤其是刚果红染色阳性是本病确诊的依据。

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