State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Peoples Republic of China.
Cell Biol Int. 2012 Aug 1;36(8):691-6. doi: 10.1042/CBI20110352.
FGF (fibroblast growth factor)/FGFR (FGF receptor) signalling plays an essential role in both endochondral and intramembranous bone development. FGF signalling pathways are important for the earliest stages of limb development and throughout skeletal development. The activity and the outcome of this signalling pathway during bone development are also influenced by many other intracellular and extracellular signals. In this review, we focus on the interplay between FGF signalling and other pathways, which is tightly regulated both spatially and temporally during endochondral skeletal development.
FGF（成纤维细胞生长因子）/FGFR（FGF 受体）信号通路在软骨内和膜内骨发育中都起着至关重要的作用。FGF 信号通路对于肢芽发育的最早阶段和整个骨骼发育都很重要。该信号通路在骨发育过程中的活性和结果也受到许多其他细胞内和细胞外信号的影响。在这篇综述中，我们重点介绍 FGF 信号通路与其他通路之间的相互作用，这种相互作用在软骨内骨骼发育过程中受到时空的严格调控。
