Immunogenetics Laboratory, Maringá State University, UEM, Maringá, PR, Brazil.
Scand J Immunol. 2012 Oct;76(4):440-7. doi: 10.1111/j.1365-3083.2012.02755.x.
The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1 11 (5.0% versus 18.2%, P=0.0016, OR=0.23, CI 95% = 0.09-0.58; Pc=0.0208) and DRB1 11-DQA1 05-DQB1 03 haplotype (4.2% versus 15.3%, P=0.0032; OR = 0.24, CI 95% = 0.08-0.64). Liver damage was associated with HLA-C 04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95%=1.97-19.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients.
本研究旨在调查慢性丙型肝炎病毒（HCV）感染患者的人类白细胞抗原（HLA）基因，并分析这些基因在慢性丙型肝炎进展中的可能作用。评估了 145 名仅感染 HCV 基因型 1 的巴西患者。通过 Luminex 技术的 PCR-SSO 进行 HLA Ⅰ类（A、B、C）和Ⅱ类（DRB1、DQA1、DQB1）基因分型。发现 DRB1 11（5.0%对 18.2%，P=0.0016，OR=0.23，95%CI=0.09-0.58；Pc=0.0208）和 DRB1 11-DQA1 05-DQB1 03 单倍型（4.2%对 15.3%，P=0.0032；OR=0.24，95%CI=0.08-0.64）对发展为肝损伤有保护作用。在感染<20 年的患者中，HLA-C 04 与肝损伤相关（38.4%对 9.1%，P=0.002，OR=6.25，95%CI=1.97-19.7；Pc=0.0238）。结论：HLA 等位基因可能影响巴西慢性 HCV 感染患者肝损伤的发展。
